Brain Tumors in Children

1999/04/01 by Roger J. Packer · 103 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Brain tumor #Brainstem #Cancer #Cancer research #Central nervous system #Chemotherapy #Childhood cancer #Chromatin Remodeling and Cancer #Glioma #Glioma Diagnosis and Treatment #Hedgehog Signaling Pathway Studies #Internal medicine #Medicine #Nervous system #Oncology #Pathology #Pediatrics #Psychiatry

paper · doi:10.1001/archneur.56.4.421

published in Archives of Neurology 56(4), 421 (American Medical Association)

openalex publication_date 1999/04/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/30

Abstract

Childhood brain tumors are the leading cause of cancer-related morbidity and mortality in the pediatric years and differ from primary central nervous system tumors occurring in adults. Management strategies must take into account not only the tumor type, but the age of the patient and the likelihood of treatment-induced nervous system damage. With current means of treatment, most children older than 3 years can be effectively treated. Chemotherapy has taken on an increasing role in the treatment of childhood medulloblastomas, low-grade gliomas, and high-grade gliomas. Some tumor types, especially atypical teratoid tumors, brainstem gliomas, malignant gliomas, and malignant infantile tumors, remain significant therapeutic dilemmas.

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