Fatigue in Multiple Sclerosis
1988/04/01 by L. B. Krupp, Lauren Krupp, Lilia Alvarez +5 · 35 citations
Medicine · #Multiple Sclerosis Research Studies #Fibromyalgia and Chronic Fatigue Syndrome Research #Peripheral Neuropathies and Disorders
paper · doi:10.1001/archneur.1988.00520280085020
Abstract
Fatigue is a frequent symptom in multiple sclerosis (MS) that can interfere with a patient's daily functioning. The cause of MS fatigue, its clinical characteristics, and its relationship to other symptoms remain poorly understood. Structured interviews were conducted with 32 patients with MS and 33 normal healthy adults. Fatigue proved to be both more frequent and more severe among the patients with MS. Multiple sclerosis fatigue was unrelated to either depression or global impairment. Multiple sclerosis fatigue appears to be a distinct clinical entity, often disabling, that can be distinguished from normal fatigue, affective disturbance, and neurologic impairment.
Cited by
- The Fatigue Severity Scale
- The multidimensional Fatigue Inventory (MFI) psychometric qualities of an instrument to assess fatigue
- Randomized controlled trial of yoga and exercise in multiple sclerosis
- Prevalence and severity of fatigue in treated hypothyroidism: results of a UK survey
- Massage therapy and exercise therapy in patients with multiple sclerosis: a randomized controlled pilot study
- Muscle abnormalities worsen after post-exertional malaise in long COVID
- Impact of Fatigue Induced by a Functional Task on Balance Control in Individuals With Multiple Sclerosis
- Blunted pressor and intramuscular metabolic responses to voluntary isometric exercise in multiple sclerosis
- Subjective fatigue and subjective sleepiness: two independent consequences of sleep disorders?
- Analyzing safety behaviors of temporary construction workers using structural equation modeling
- fMRI changes in relapsing-remitting multiple sclerosis patients complaining of fatigue after IFNbeta-1a injection. [europepmc]
- Fatigue in osteoarthritis: a qualitative study. [europepmc]
- Depression and immunity: inflammation and depressive symptoms in multiple sclerosis. [europepmc]
- Drug therapy for the management of cancer-related fatigue. [europepmc]
- Relationship between depression, fatigue, subjective cognitive impairment, and objective neuropsychological functioning in patients with multiple sclerosis. [europepmc]
- Sensitivity to heat in MS patients: a factor strongly influencing symptomology--an explorative survey. [europepmc]
- Sleep-disordered breathing in multiple sclerosis. [europepmc]
- Work capacity and health-related quality of life among individuals with multiple sclerosis reduced by fatigue: a cross-sectional study. [europepmc]
- Examination of cognitive fatigue in multiple sclerosis using functional magnetic resonance imaging and diffusion tensor imaging. [europepmc]
- Obstructive sleep apnea and fatigue in patients with multiple sclerosis. [europepmc]
- Physical disability, anxiety and depression in people with MS: an internet-based survey via the UK MS Register. [europepmc]
- Subjective cognitive fatigue in multiple sclerosis depends on task length. [europepmc]
- The representation of inflammatory signals in the brain - a model for subjective fatigue in multiple sclerosis. [europepmc]
- Pain affects depression through anxiety, fatigue, and sleep in multiple sclerosis. [europepmc]
- Fatigue in multiple sclerosis: a look at the role of poor sleep. [europepmc]
- Fatigue in Multiple Sclerosis: Neural Correlates and the Role of Non-Invasive Brain Stimulation. [europepmc]
- Disease-Induced Skeletal Muscle Atrophy and Fatigue. [europepmc]
- Ecological Momentary Assessment of Pain, Fatigue, Depressive, and Cognitive Symptoms Reveals Significant Daily Variability in Multiple Sclerosis. [europepmc]
- How Do Pain, Fatigue, Depressive, and Cognitive Symptoms Relate to Well-Being and Social and Physical Functioning in the Daily Lives of Individuals With Multiple Sclerosis? [europepmc]
- Salivary biomarkers for the diagnosis and monitoring of neurological diseases. [europepmc]
- Neutrophil-selective deletion of Cxcr2 protects against CNS neurodegeneration in a mouse model of multiple sclerosis. [europepmc]
- Non-Pharmacological Interventions for Post-Stroke Fatigue: Systematic Review and Network Meta-Analysis. [europepmc]
- Fatigue in patients with chronic disease: results from the population-based Lifelines Cohort Study. [europepmc]
- The relationship between fatigue, sleep quality, resilience, and the risk of postpartum depression: an emphasis on maternal mental health. [europepmc]
- Muscle abnormalities worsen after post-exertional malaise in long COVID. [europepmc]
Related