2024/04/29 by Ren-Yi Wang, Wang, Ren-Yi, Marek Kimmel +3 · 1 citation
Medicine · #FOS: Biological sciences #Mathematical and Theoretical Epidemiology and Ecology Models #Populations and Evolution (q-bio.PE)
paper · pdf · doi:10.48550/arxiv.2404.19041
openalex publication_date 2024/04/29 · openalex created_date 2024/05/11 · openalex updated_date 2026/07/28
We present an asymptotic analysis of a stochastic two-compartmental cell division system with regulatory mechanisms inspired by Getto et al. (2013). The hematopoietic system is modeled as a two-compartment system, where the first compartment consists of dividing cells in the bone marrow, referred to as type 0 cells, and the second compartment consists of post-mitotic cells in the blood, referred to as type 1 cells. Division and self-renewal of type 0 cells are regulated by the population density of type 1 cells. By scaling up the initial population, we demonstrate that the scaled dynamics converges in distribution to the solution of a system of ordinary differential equations (ODEs). This system of ODEs exhibits a unique non-trivial equilibrium that is globally stable. Furthermore, we establish that the scaled fluctuations of the density dynamics converge in law to a linear diffusion process with time-dependent coefficients. When the initial data is Gaussian, the limit process is a Gauss-Markov process. We analyze its asymptotic properties to elucidate the joint structure of both compartments over large times. This is achieved by proving exponential convergence in the 2-Wasserstein metric for the associated Gaussian measures on an L2 Hilbert space. Finally, we apply our results to compare the effects of regulating division and self-renewal of type 0 cells, providing insights into their respective roles in maintaining hematopoietic system stability.