1985/10/01 by Israel Heller · 4 citations
Medicine · #Acetazolamide #Acidosis #Anesthesia #Cardiac Arrest and Resuscitation #Clinical significance #Internal medicine #Medicine #Metabolic acidosis #Respiratory Support and Mechanisms #Traumatic Brain Injury and Neurovascular Disturbances
paper · doi:10.1001/archinte.1985.00360100075012
openalex publication_date 1985/10/01 · openalex created_date 2016/06/24 · openalex updated_date 2026/07/30
Blood gas and serum electrolyte levels were measured in 27 elderly patients (mean age +/- SD, 63.3 +/- 13.5 years) who were receiving acetazolamide (250 to 1,000 mg/day) for glaucoma. Eleven glaucomatous patients (mean age, 69.1 +/- 7.4 years) who were not receiving acetazolamide served as a control group. In the acetazolamide-treated group, four patients (14.8%) had mild acidosis (7.29 greater than pH less than or equal to 7.31), ten (37%) had moderate acidosis (7.20 greater than pH less than or equal to 7.29), and one patient (3.7%) had severe acidosis (pH, 7.15). None of the patients in the control group had acidosis. It is concluded that moderate metabolic acidosis of potential clinical significance is common among glaucomatous elderly patients who receive acetazolamide. The exact clinical significance of our observations is yet to be determined.