Changes in Cortical Thickness During the Course of Illness in Schizophrenia
2011/09/01 by Neeltje E. M. van Haren, Neeltje E.M. van Haren · 400 citations
Medicine · Neuroscience · Psychology · #Advanced Neuroimaging Techniques and Applications #Antipsychotic #Cardiology #Cerebral cortex #Cognition #Cortex (anatomy) #Functional Brain Connectivity Studies #Medicine #Neuroscience #Orbitofrontal cortex #Prefrontal cortex #Psychiatry #Psychology #Psychosis #Schizophrenia (object-oriented programming) #Schizophrenia research and treatment
paper · open access · doi:10.1001/archgenpsychiatry.2011.88
published in Archives of General Psychiatry 68(9), 871 (American Medical Association)
openalex publication_date 2011/09/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/30
Abstract
CONTEXT: Whether cortical thickness changes in schizophrenia over time are more pronounced relative to the changes that can be attributed to normal aging has not been studied. OBJECTIVE: To compare patients with schizophrenia and healthy control participants on cortical thickness change. DESIGN: A 5-year longitudinal study comparing schizophrenic patients and healthy controls using 2 magnetic resonance images of the brain. SETTING: Patients were recruited from the Department of Psychiatry at the University Medical Centre Utrecht and from other psychiatric hospitals in the Netherlands. Healthy controls were recruited via advertisement in newspapers and notice boards. PARTICIPANTS: Ninety-six schizophrenic patients and 113 healthy controls aged 16 to 56 years. MAIN OUTCOME MEASURES: Cortical thickness and change in cortical thickness on a vertex-by-vertex basis across the cortical mantle, measures of functional and symptomatic outcome, and cumulative intake of antipsychotics during the scan interval. RESULTS: At baseline, the schizophrenic patients had thinner left orbitofrontal and right parahippocampal and superior temporal cortices and a thicker superior parietal lobule and occipital pole compared with the controls. Mean cortical thickness did not differ between the groups. Over time, excessive cortical thinning was found in widespread areas on the cortical mantle, most pronounced bilaterally in the temporal cortex and in the left frontal area. Poor outcome in patients was associated with more pronounced cortical thinning. Higher cumulative intake of typical antipsychotics during the scan interval was associated with more pronounced cortical thinning, whereas higher cumulative intake of atypical antipsychotic medication was associated with less pronounced cortical thinning. CONCLUSIONS: In schizophrenia, the cortex shows excessive thinning over time in widespread areas of the brain, most pronounced in the frontal and temporal areas, and progresses across the entire course of the illness. The excessive thinning of the cortex appears related to outcome and medication intake.
Citations
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- Cortical thinning in psychopathy. [europepmc]
- Longitudinal progression of frontal and temporal lobe changes in schizophrenia. [europepmc]
- Using multivariate machine learning methods and structural MRI to classify childhood onset schizophrenia and healthy controls. [europepmc]
- Cortical folding defects as markers of poor treatment response in first-episode psychosis. [europepmc]
- Morphometry of superior temporal gyrus and planum temporale in schizophrenia and psychotic bipolar disorder. [europepmc]
- Glutamate-mediated excitotoxicity in schizophrenia: a review. [europepmc]
- A multimodal analysis of antipsychotic effects on brain structure and function in first-episode schizophrenia. [europepmc]
- Reduced cortical thickness in right Heschl's gyrus associated with auditory verbal hallucinations severity in first-episode schizophrenia. [europepmc]
- Brain Structural Effects of Antipsychotic Treatment in Schizophrenia: A Systematic Review. [europepmc]
- Allostatic load and reduced cortical thickness in schizophrenia. [europepmc]
- Positive symptoms associate with cortical thinning in the superior temporal gyrus via the ENIGMA Schizophrenia consortium. [europepmc]
- Prefrontal cortical thinning links to negative symptoms in schizophrenia via the ENIGMA consortium. [europepmc]
- DNA methylation age is not accelerated in brain or blood of subjects with schizophrenia. [europepmc]
- A Network Neuroscience Approach to Typical and Atypical Brain Development. [europepmc]
- Cortical Brain Abnormalities in 4474 Individuals With Schizophrenia and 5098 Control Subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium. [europepmc]
- Brain structure, cognition, and brain age in schizophrenia, bipolar disorder, and healthy controls. [europepmc]
- The role of the retinoids in schizophrenia: genomic and clinical perspectives. [europepmc]
- Characteristics of gray matter alterations in never-treated and treated chronic schizophrenia patients. [europepmc]
- Pervasively Thinner Neocortex as a Transdiagnostic Feature of General Psychopathology. [europepmc]
- Biotyping in psychosis: using multiple computational approaches with one data set. [europepmc]
- Differentiating the effect of antipsychotic medication and illness on brain volume reductions in first-episode psychosis: A Longitudinal, Randomised, Triple-blind, Placebo-controlled MRI Study. [europepmc]
- Brain age prediction in schizophrenia: Does the choice of machine learning algorithm matter? [europepmc]
- Factors associated with brain ageing - a systematic review. [europepmc]
- Structural and Functional Deviations of the Hippocampus in Schizophrenia and Schizophrenia Animal Models. [europepmc]
- Evidence for embracing normative modeling. [europepmc]
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