Caudate Glucose Metabolic Rate Changes With Both Drug and Behavior Therapy for Obsessive-Compulsive Disorder

1992/09/01 by Lewis R. Baxter, L.R. Baxter · 1,303 citations
Medicine · Neuroscience · Psychology · #Anesthesia #Autism Spectrum Disorder Research #Caudate nucleus #Endocrinology #Fluoxetine #Internal medicine #Medicine #Neuroscience #Neurotransmitter Receptor Influence on Behavior #Obsessive compulsive #Obsessive-Compulsive Spectrum Disorders #Psychiatry #Psychology #Thalamus

paper · doi:10.1001/archpsyc.1992.01820090009002

published in Archives of General Psychiatry 49(9), 681 (American Medical Association)

openalex publication_date 1992/09/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/30

Abstract

We used positron emission tomography to investigate local cerebral metabolic rates for glucose (LCMRG1c) in patients with obsessive-compulsive disorder before and after treatment with either fluoxetine hydrochloride or behavior therapy. After treatment, LCMRG1c in the head of the right caudate nucleus, divided by that in the ipsilateral hemisphere (Cd/hem), was decreased significantly compared with pretreatment values in responders to both drug and behavior therapy. These decreases in responders were also significantly greater than right Cd/hem changes in nonresponders and normal controls, in both of whom values did not change from baseline. Percentage change in obsessive-compulsive disorder symptom ratings correlated significantly with the percent of right Cd/hem change with drug therapy and there was a trend to significance for this same correlation with behavior therapy. By lumping all responders to either treatment, right orbital cortex/hem was significantly correlated with ipsilateral Cd/hem and thalamus/hem before treatment but not after, and the differences before and after treatment were significant. A similar pattern was noted in the left hemisphere. A brain circuit involving these brain regions may mediate obsessive-compulsive disorder symptoms.

Citations

• The Yale-Brown Obsessive Compulsive Scale

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