1977/10/01 by Norman M. Price
Medicine · Biochemistry, Genetics and Molecular Biology · #Ocular Oncology and Treatments #Drug-Induced Ocular Toxicity #melanin and skin pigmentation
paper · doi:10.1001/archderm.1977.01640100065010
• Six patients with mycosis fungoides were treated with topical mechlorethamine hydrochloride for periods of two to four years. Clinical and histological studies for radiomimetic and radiodermatitis-like effects failed to demonstrate any abnormalities. The only observed changes were generalized hyperpigmentation of the skin and melanin-containing melanophages in the papillary dermis. We consider that the long-term use of topical mechlorethamine may be a safe form of therapy, but that a continuous indefinite follow-up of patients on this medication should be mandatory. (<i>Arch Dermatol</i>113:1387-1389, 1977)