1997/03/01 by Jeff T. Reed · 2 citations
Pharmacology, Toxicology and Pharmaceutics · Medicine · #Advancements in Transdermal Drug Delivery #Dermatology and Skin Diseases #Contact Dermatitis and Allergies
paper · doi:10.1001/archderm.1997.03890390139031
Until recently, skin aging was largely equated with photoaging, and the abnormalities in photoaging have been largely localized to the dermis. Recent studies<sup>1</sup>have shown that chronological aging alone produces important abnormalities in epidermal function that are revealed only when the skin barrier is perturbed. These alterations include a profound abnormality in stratum corneum integrity (cohesiveness) and permeability barrier homeostasis, reflected by a delay in barrier recovery after barrier disruption.<sup>1</sup>We explored whether photoaging imposes an additional functional deficit on chronologically aged (CA) skin (<b>Table</b>).<sup>2,3</sup> <h3>Assessment of Barrier Function Under Basal Conditions.</h3> Prior studies<sup>1</sup>from our and other laboratories have shown that barrier function under basal conditions in nonphotoaged, CA skin is slightly lower than normal. Furthermore, in a pilot study in young people (20-30 years old), we confirmed the finding of others<sup>4,5</sup>that there is no significant difference in volar vs dorsal forearm transepidermal