2025/06/16 by Catherine E. Apgar, Apgar, Catherine E., Andrew S. Voyles +21
Environmental Science · Medicine · #Chemical Synthesis and Characterization #FOS: Physical sciences #Medical Imaging and Pathology Studies #Nuclear Experiment (nucl-ex) #Radiopharmaceutical Chemistry and Applications
paper · pdf · doi:10.48550/arxiv.2506.13948
openalex publication_date 2025/06/16 · openalex created_date 2025/10/18 · openalex updated_date 2026/07/28
\mathrm117mSn and \mathrm119Sb, the latter of which is produced via a \mathrm119mTe generator, are promising radionuclides for the targeted treatment of both osteoarthritis and small mass tumors via Auger therapy. Experiments were conducted at Lawrence Berkeley National Laboratory, Los Alamos National Laboratory, and Brookhaven National Laboratory to measure the \mathrmnatSb(p,x)\mathrm117mSn and \mathrmnatSb(p,x)\mathrm119mTe cross sections for incident proton energies up to 200 MeV. Additional measurements for co-produced isotopes are included as well. In addition to this dataset, this paper investigates improvements for proton-induced reaction modeling capabilities through comparison of these experimental dataset against theoretical models in TALYS 1.95. Parameter adjustments affecting level density, optical model potential, and pre-equilibrium emission were explored, with a goodness-of-fit metric established by the largest independent cross section channels and cross-validated with remaining channels.