Incidence Estimate of Nonmelanoma Skin Cancer in the United States, 2006
2010/03/01 by Howard W. Rogers, Martin A. Weinstock, Ashlynne R. Harris +5 · 1,185 citations
Medicine · #Cancer #Census #Cutaneous Melanoma Detection and Management #Demography #Environmental health #Family medicine #Health care #Incidence (geometry) #Internal medicine #Medicaid #Medicine #Nonmelanoma Skin Cancer Studies #Population #Skin Protection and Aging #Skin cancer
paper · pdf · doi:10.1001/archdermatol.2010.19
published in Archives of Dermatology 146(3), 283-7 (American Medical Association)
openalex publication_date 2010/03/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/05
Abstract
OBJECTIVES: To estimate the incidence of nonmelanoma skin cancer (NMSC) in the US population in 2006 and secondarily to indicate trends in numbers of procedures for skin cancer treatment. DESIGN: A descriptive analysis of population-based claims and US Census Bureau data combined with a population-based cross-sectional survey using multiple US government data sets, including the Centers for Medicare and Medicaid Services Fee-for-Service Physicians Claims databases, to calculate totals of skin cancer procedures performed for Medicare beneficiaries in 1992 and from 1996 to 2006 and related parameters. The National Ambulatory Medical Care Service database was used to estimate NMSC-related office visits. We combined these to estimate totals of new skin cancer diagnoses and affected individuals in the overall US population. RESULTS: The total number of procedures for skin cancer in the Medicare fee-for-service population increased by 76.9% from 1 158 298 in 1992 to 2 048 517 in 2006. The age-adjusted procedure rate per year per 100 000 beneficiaries increased from 3514 in 1992 to 6075 in 2006. From 2002 to 2006 (the years for which the databases allow procedure linkage to patient demographics and diagnoses), the number of procedures for NMSC in the Medicare population increased by 16.0%. In this period, the number of procedures per affected patient increased by 1.5%, and the number of persons with at least 1 procedure increased by 14.3%. We estimate the total number of NMSCs in the US population in 2006 at 3 507 693 and the total number of persons in the United States treated for NMSC at 2 152 500. CONCLUSIONS: The number of skin cancers in Medicare beneficiaries increased dramatically over the years 1992 to 2006, due mainly to an increase in the number of affected individuals. Using nationally representative databases, we provide evidence of much higher overall totals of skin cancer diagnoses and patients in the US population than previous estimates. These data give the most complete evaluation to date of the underrecognized epidemic of skin cancer in the United States.
Cited by
- In Vivo CRISPR Interference Screen Reveals Long Noncoding RNA Portfolio Crucial for Cutaneous Squamous Cell Carcinoma Tumor Growth
- Nonmelanoma Skin Cancer
- AAD/ACMS/ASDSA/ASMS 2012 appropriate use criteria for Mohs micrographic surgery: A report of the American Academy of Dermatology, American College of Mohs Surgery, American Society for Dermatologic Surgery Association, and the American Society for Mohs Surgery
- Epidemiology and Economic Burden of Nonmelanoma Skin Cancer
- Recent advances in the prevention and treatment of skin cancer using photodynamic therapy. [europepmc]
- Cancer and neurologic degeneration in xeroderma pigmentosum: long term follow-up characterises the role of DNA repair. [europepmc]
- The grape antioxidant resveratrol for skin disorders: promise, prospects, and challenges. [europepmc]
- Roles of the immune system in skin cancer. [europepmc]
- From keratinocyte to cancer: the pathogenesis and modeling of cutaneous squamous cell carcinoma. [europepmc]
- ZNF750 is a p63 target gene that induces KLF4 to drive terminal epidermal differentiation. [europepmc]
- Risk of melanoma and nonmelanoma skin cancer among patients with inflammatory bowel disease. [europepmc]
- Efficacy and safety of vismodegib in advanced basal-cell carcinoma. [europepmc]
- Tumor recurrence 5 years after treatment of cutaneous basal cell carcinoma and squamous cell carcinoma. [europepmc]
- International prevalence of indoor tanning: a systematic review and meta-analysis. [europepmc]
- Role of human papillomavirus in cutaneous squamous cell carcinoma: a meta-analysis. [europepmc]
- Addressing overdiagnosis and overtreatment in cancer: a prescription for change. [europepmc]
- Long-term ultraviolet flux, other potential risk factors, and skin cancer risk: a cohort study. [europepmc]
- SIRT6 promotes COX-2 expression and acts as an oncogene in skin cancer. [europepmc]
- Prevalence and costs of skin cancer treatment in the U.S., 2002-2006 and 2007-2011. [europepmc]
- Genomic analysis of metastatic cutaneous squamous cell carcinoma. [europepmc]
- Ultraviolet radiation-induced non-melanoma skin cancer: Regulation of DNA damage repair and inflammation. [europepmc]
- Smoothened variants explain the majority of drug resistance in basal cell carcinoma. [europepmc]
- Risk Factors for Cutaneous Squamous Cell Carcinoma Recurrence, Metastasis, and Disease-Specific Death: A Systematic Review and Meta-analysis. [europepmc]
- Reflectance confocal microscopy of skin in vivo: From bench to bedside. [europepmc]
- Autophagy gene ATG7 regulates ultraviolet radiation-induced inflammation and skin tumorigenesis. [europepmc]
- Updates on the Management of Non-Melanoma Skin Cancer (NMSC). [europepmc]
- Epithelial damage and tissue γδ T cells promote a unique tumor-protective IgE response. [europepmc]
- Keratinocyte Carcinomas: Current Concepts and Future Research Priorities. [europepmc]
- Pilot Phase II Trial of Neoadjuvant Immunotherapy in Locoregionally Advanced, Resectable Cutaneous Squamous Cell Carcinoma of the Head and Neck. [europepmc]
Related