Lipid peroxidation as measured by chromatographic determination of malondialdehyde. Human plasma reference values in health and disease
2021/06/17 by Cristina Mas‐Bargues, Cristina Mas-Bargues, Consuelo Escrivá +4 · 25 citations
Medicine · Nursing · #Antioxidant Activity and Oxidative Stress #Vitamin C and Antioxidants Research #Adipose Tissue and Metabolism
paper · doi:10.1016/j.abb.2021.108941
Abstract
Free radicals and oxidants are involved in physiological signaling pathways, although an imbalance between pro-oxidant and anti-oxidant systems in favor of the former leads to major biomolecular damage. This is the so-called oxidative stress, a complex process that affects us all and is responsible for the development of many diseases. Lipids are very sensitive to oxidant attack and to-date, malondialdehyde (MDA), 4-hydroxy-2-nonenal (4-HNE) and F2-isoprostane are the main biomarkers for lipid peroxidation assessment. They all derive from polyunsaturated fatty acids (PUFAs) either by enzyme-catalyzed reactions (physiological) or by non-enzyme reactions (pathological). The profile of PUFAs present in the tissue will determine the proportion of each biomarker. In this review we aim to discuss the proper method for MDA determination using HPLC. We also offer reference MDA values in humans in physiological and pathological conditions.
Cited by
- Analytical Methods for Lipid Oxidation and Antioxidant Capacity in Food Systems. [europepmc]
- Lipid peroxidation as a hallmark of severity in COVID-19 patients. [europepmc]
- Hispidulin Ameliorates Endotoxin-Induced Acute Kidney Injury in Mice. [europepmc]
- Metabolic and Molecular Mechanisms of Diet and Physical Exercise in the Management of Polycystic Ovarian Syndrome. [europepmc]
- Frailty in Aging and the Search for the Optimal Biomarker: A Review. [europepmc]
- Comparative Analysis of the Pre- and Post-Medication Effects of Antipsychotic Agents on the Blood-Based Oxidative Stress Biomarkers in Patients with Schizophrenia: A Meta-Analysis. [europepmc]
- Effects of Selected Metal Nanoparticles (Ag, ZnO, TiO 2 ) on the Structure and Function of Reproductive Organs. [europepmc]
- Detrimental Effects of Lipid Peroxidation in Type 2 Diabetes: Exploring the Neutralizing Influence of Antioxidants. [europepmc]
- ROS: Basic Concepts, Sources, Cellular Signaling, and its Implications in Aging Pathways. [europepmc]
- Mechanistic View on the Effects of SGLT2 Inhibitors on Lipid Metabolism in Diabetic Milieu. [europepmc]
- Anti-Aging Effect of Agrocybe aegerita Polysaccharide through Regulation of Oxidative Stress and Gut Microbiota. [europepmc]
- Oxidative Stress and Air Pollution: Its Impact on Chronic Respiratory Diseases. [europepmc]
- Alopecia Areata: A Review of the Role of Oxidative Stress, Possible Biomarkers, and Potential Novel Therapeutic Approaches. [europepmc]
- Early Detection Is the Best Prevention-Characterization of Oxidative Stress in Diabetes Mellitus and Its Consequences on the Cardiovascular System. [europepmc]
- Prognostic Value of Malondialdehyde (MDA) in the Temporal Progression of Chronic Spinal Cord Injury. [europepmc]
- Terpenes: Modulating anti-inflammatory signaling in inflammatory bowel disease. [europepmc]
- Biochemical-molecular-genetic biomarkers in the tear film, aqueous humor, and blood of primary open-angle glaucoma patients. [europepmc]
- Lipid peroxidation in osteoarthritis: focusing on 4-hydroxynonenal, malondialdehyde, and ferroptosis. [europepmc]
- Inflammasome activity regulation by PUFA metabolites. [europepmc]
- Iron-based MOF with Catalase-like activity improves the synergistic therapeutic effect of PDT/ferroptosis/starvation therapy by reversing the tumor hypoxic microenvironment. [europepmc]
- Up-regulated succinylation modifications induce a senescence phenotype in microglia by altering mitochondrial energy metabolism. [europepmc]
- Ferroptosis and its role in osteoarthritis: mechanisms, biomarkers, and therapeutic perspectives. [europepmc]
- New advances in biological preservation technology for aquatic products. [europepmc]
- Antioxidants in cancer therapy mitigating lipid peroxidation without compromising treatment through nanotechnology. [europepmc]
- Reactive Oxygen Species Across Death Pathways: Gatekeepers of Apoptosis, Ferroptosis, Pyroptosis, Paraptosis, and Beyond. [europepmc]
Related