Molecular Cloning, Expression, and Characterization of Amorpha-4,11-diene Synthase, a Key Enzyme of Artemisinin Biosynthesis in Artemisia annua L.

2000/09/01 by Per Mercke, P. Mercke, Marie Bengtsson +3 · 26 citations
Biochemistry, Genetics and Molecular Biology · Pharmacology, Toxicology and Pharmaceutics · Agricultural and Biological Sciences · #Plant biochemistry and biosynthesis #Pharmacological Effects of Natural Compounds #Essential Oils and Antimicrobial Activity

paper · doi:10.1006/abbi.2000.1962

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• Abscisic acid (ABA) treatment increases artemisinin content in Artemisia annua by enhancing the expression of genes in artemisinin biosynthetic pathway
• Structure of trichodiene synthase from Fusarium sporotrichioides provides mechanistic inferences on the terpene cyclization cascade. [europepmc]
• Recent advances in artemisinin production through heterologous expression. [europepmc]
• Global characterization of Artemisia annua glandular trichome transcriptome using 454 pyrosequencing. [europepmc]
• Sesquiterpene synthases Cop4 and Cop6 from Coprinus cinereus: catalytic promiscuity and cyclization of farnesyl pyrophosphate geometric isomers. [europepmc]
• The biosynthesis of artemisinin (Qinghaosu) and the phytochemistry of Artemisia annua L. (Qinghao). [europepmc]
• Relative expression of genes of terpene metabolism in different tissues of Artemisia annua L. [europepmc]
• Trichomes + roots + ROS = artemisinin: regulating artemisinin biosynthesis in Artemisia annua L. [europepmc]
• The organ-specific expression of terpene synthase genes contributes to the terpene hydrocarbon composition of chamomile essential oils. [europepmc]
• The effect of roots and media constituents on trichomes and artemisinin production in Artemisia annua L. [europepmc]
• Molecular Farming in Artemisia annua, a Promising Approach to Improve Anti-malarial Drug Production. [europepmc]
• Artemisinin-based antimalarial research: application of biotechnology to the production of artemisinin, its mode of action, and the mechanism of resistance of Plasmodium parasites. [europepmc]
• A Review of Biotechnological Artemisinin Production in Plants. [europepmc]
• Detailed Phytochemical Analysis of High- and Low Artemisinin-Producing Chemotypes of Artemisia annua . [europepmc]
• Catalysis of amorpha-4,11-diene synthase unraveled and improved by mutability landscape guided engineering. [europepmc]
• Expression of key genes affecting artemisinin content in five Artemisia species. [europepmc]
• Interaction of bZIP transcription factor TGA6 with salicylic acid signaling modulates artemisinin biosynthesis in Artemisia annua. [europepmc]
• Insights into Heterologous Biosynthesis of Arteannuin B and Artemisinin in Physcomitrella patens . [europepmc]
• Medically Useful Plant Terpenoids: Biosynthesis, Occurrence, and Mechanism of Action. [europepmc]
• Glandular trichomes: new focus on horticultural crops. [europepmc]
• Enhancing artemisinin content in and delivery from Artemisia annua: a review of alternative, classical, and transgenic approaches. [europepmc]
• Artemisinins in Combating Viral Infections Like SARS-CoV-2, Inflammation and Cancers and Options to Meet Increased Global Demand. [europepmc]
• Biosynthesis Investigations of Terpenoid, Alkaloid, and Flavonoid Antimicrobial Agents Derived from Medicinal Plants. [europepmc]
• From Plant to Yeast-Advances in Biosynthesis of Artemisinin. [europepmc]
• Plant terpene specialized metabolism: complex networks or simple linear pathways? [europepmc]
• Plant sesquiterpene lactones. [europepmc]