Differential phosphorylation of LZ+/LZ− MYPT1 isoforms regulates MLC phosphatase activity

2014/08/26 by Samantha L. Yuen, Ozgur Ogut, Frank V. Brozovich · 14 citations
Biochemistry, Genetics and Molecular Biology · #Protein Kinase Regulation and GTPase Signaling #Protein Tyrosine Phosphatases #Cancer, Hypoxia, and Metabolism

paper · doi:10.1016/j.abb.2014.08.011

Citations

• Myosin phosphatase isoform switching in vascular smooth muscle development
• Captopril prevents myosin light chain phosphatase isoform switching to preserve normal cGMP-mediated vasodilatation

Cited by

• Alanine mutation of the targeting subunit of the myosin phosphatase, MYPT1 at threonine 696 reduces cGMP responsiveness of mouse femoral arteries
• Calcium Sensitization Mechanisms in Gastrointestinal Smooth Muscles. [europepmc]
• MYPT1 isoforms expressed in HEK293T cells are differentially phosphorylated after GTPγS treatment. [europepmc]
• Unfair competition governs the interaction of pCPI-17 with myosin phosphatase (PP1-MYPT1). [europepmc]
• Regulation of Pulmonary Vascular Smooth Muscle Contractility in Pulmonary Arterial Hypertension: Implications for Therapy. [europepmc]
• Alternative splicing of (ppp1r12a/mypt1) in zebrafish produces a novel myosin phosphatase targeting subunit. [europepmc]
• Oxidation of cysteine 117 stimulates constitutive activation of the type Iα cGMP-dependent protein kinase. [europepmc]
• Augmented contractility of murine femoral arteries in a streptozotocin diabetes model is related to increased phosphorylation of MYPT1. [europepmc]
• The vasculature in HFpEF vs HFrEF: differences in contractile protein expression produce distinct phenotypes. [europepmc]
• Constitutive protein kinase G activation exacerbates stress-induced cardiomyopathy. [europepmc]
• Tissue-specific expression of myosin phosphatase subunits and isoforms in smooth muscle of mice and humans. [europepmc]
• Aging related decreases in NM myosin expression and contractility in a resistance vessel. [europepmc]
• MBNL loss of function in smooth muscle as a model for myotonic dystrophy associated gastrointestinal dysmotility. [europepmc]
• Unresolved mechanisms: a hypothesized spatial regulation of myosin light chain phosphorylation within the walls of resistance arteries. [europepmc]