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Modeling the influence of TH1 and TH2 type cells in autoimmune diseases

2000/06/19 by Y. Louzoun, Yoram Louzoun, Louzoun, Y. +5
Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · Mathematics · #92B08 #Diabetes and associated disorders #Dynamical Systems (math.DS) #FOS: Biological sciences #FOS: Mathematics #Immune Cell Function and Interaction #Quantitative Biology (q-bio) #T-cell and B-cell Immunology #math.DS #msc:92B08 #q-bio

paper · pdf · doi:10.48550/arxiv.math/0006127

24 pages, 8 figures, 1 table

arxiv created 2000/06/19 · openalex publication_date 2000/06/19 · arxiv updated 2009/11/30 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28

Abstract

A sharp TH1/TH2 dichotomy has often been used to define the effects of cytokines on autoimmune diseases. However contradictory results in recent research indicate that the situation may be more complex. We build here a simple mathematical model aimed at settling the contradictions. The model is based on a neural network paradigm, and is applied using Partial Differential Equations (PDE). We show here that a TH1/TH2 paradigm is only an external view of a complex multivariate system.

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