2015/10/14 by N. Ramakrishnan, Ramakrishnan, N., Kripa Gowrishankar +8 · 1 citation
Biochemistry, Genetics and Molecular Biology · Physics and Astronomy · #Biological Physics (physics.bio-ph) #FOS: Physical sciences #Genomics and Chromatin Dynamics #Protein Degradation and Inhibitors #Protein Structure and Dynamics #Soft Condensed Matter (cond-mat.soft) #Statistical Mechanics (cond-mat.stat-mech) #cond-mat.soft #cond-mat.stat-mech #physics.bio-ph
paper · pdf · doi:10.48550/arxiv.1510.04157
18pages and 4 figures in main article and 27pages of SI with 20 figures
arxiv created 2015/10/14 · openalex publication_date 2015/10/14 · arxiv updated 2015/10/15 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
Recent high resolution experiments have provided a quantitative description of the statistical properties of interphase chromatin at large scales. These findings have stimulated a search for generic physical interactions that give rise to such specific statistical conformations. Here, we show that an active chromatin model of in-vivo folding, based on the interplay between polymer elasticity, confinement, topological constraints and active stresses arising from the (un)binding of ATP-dependent chromatin-remodeling proteins gives rise to steady state conformations consistent with these experiments. Our results lead us to conjecture that the chromatin conformation resulting from this active folding optimizes information storage by co-locating gene loci which share transcription resources.