2023/03/29 by Hartwig, Andrea, MAK Commission
#1-Methyl-1-propanethiol #1-Methyl-1-propanthiol #2-Butanethiol #2-Butanthiol #Butan-2-thiol #Butane-2-thiol #Geruchs-assoziierte Symptome #Hautresorption #Hämatotoxizität #Lebensmittelzusatzstoff #Luft #MAK value #MAK-Wert #Mercaptane #Odorierungszusatz #Reizwirkung #Thiole #Toxizität #air #food additive #haematotoxicity #irritation #maximale Arbeitsplatzkonzentration #maximum workplace concentration #mercaptans #odour-associated symptoms #odouration additive #olfactory epithelium #olfaktorisches Epithel #sec-Butanethiol #sec-Butanthiol #sec-Butyl mercaptan #sec-Butylmercaptan #skin absorption #thiols #toxicity
paper · doi:10.34865/mb51353e8_1or
The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has evaluated data for 2-butanethiol [513-53-1] considering all toxicological end points. Data from a 90-day inhalation study with rats show that the critical effects are haematotoxicity and histopathological alterations in the nasal olfactory epithelium. On the basis of the NOAEC of 25 ml/m3 for systemic toxicity and taking into account the increased respiratory volume at the workplace, the maximum concentration at the workplace (MAK value) has been set at 2 ml/m3. Local effects in the nose can be ruled out at this concentration. As the critical effect is systemic, Peak Limitation Category II has been assigned with an excursion factor of 2. As data for developmental toxicity are not available, 2-butanethiol has been classified in Pregnancy Risk Group D. According to skin absorption models, percutaneous absorption is expected to contribute significantly to systemic toxicity. Therefore, 2-butanethiol has been designated with an “H”. No studies of the sensitizing, genotoxic or carcinogenic potential of the substance are available.