2021/09/30 by Jäger, Thomas, Bader, Michael, Göen, Thomas +3
#Humanbiomonitoring #Kurzzeitexposition #Probenahmezeitpunkt #accident-related events #human biomonitoring #sampling time #short-term exposure #unfallartige Ereignisse
paper · doi:10.34865/bbgeneraldgt6_3or
Human biomonitoring (HBM) is a well-established tool in occupational medicine, particularly for the prevention of health effects after chronic exposure. However, there are also exceptional short-term exposures or accident-related events which require a toxicological risk assessment. The German Permanent Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area deliberated and summarised basic information and recommendations on human biomonitoring after acute exposure. The design and implementation of sampling procedures, e. g. the choice of the sampling time, biological material and target biomarkers, must be carried out with special attention to validity and interpretability of the analytical results. Since no specific assessment values for HBM results after acute short-term exposure are currently available, the medical-toxicological evaluation and communication could use the established assessment values for long-term exposure as a rough benchmark. But this approach requires the additional consideration of specific toxicokinetics of the hazardous substance and the target biomarker as well as of the exposure situation, i. e. duration and route of exposure.