2021/10/23 by J. A. Cowan, R. J. Furnstahl, Cowan, J. A. +1
Biochemistry, Genetics and Molecular Biology · Chemistry · Physics and Astronomy · #Astrophysics of Galaxies (astro-ph.GA) #Biological Physics (physics.bio-ph) #Chemical Physics (physics.chem-ph) #FOS: Physical sciences #Molecular spectroscopy and chirality #Origins and Evolution of Life #RNA and protein synthesis mechanisms #astro-ph.GA #physics.bio-ph #physics.chem-ph
paper · pdf · doi:10.48550/arxiv.2110.12232
18 pages, 1 figures; supplementary material included with 9 pages, 4 figures
arxiv created 2021/10/23 · openalex publication_date 2021/10/23 · arxiv updated 2021/10/26 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
Molecular chirality is inherent to biology and cellular chemistry. In this report, the origin of enantiomeric selectivity is analyzed from the viewpoint of the "RNA World" model, based on the autocatalytic self-replication of glyceraldehyde as a precursor for simple sugars, and in particular ribose, as promoted by the formose reaction. Autocatalytic coupling of formaldehyde and glycolaldehyde produces glyceraldehyde, which contains a chiral carbon center that is carried through in formation of the ribose ring. The parity non-conserving weak interaction is the only inherently handed property in nature and is herein shown to be sufficient to differentiate between two enantiomeric forms in an autocatalytic reaction performed over geologically relevant time scales, but only in the presence of a catalytic metal ion such as divalent calcium or higher Z alkaline earth elements. This work details calculations of the magnitude of the effect, the impact of various geologically-available metal ions, and the influence on evolution and dominance of chirality in the molecules of life.