Knee and hip articular cartilage have distinct epigenomic landscapes: implications for future cartilage regeneration approaches

2014/09/27 by Wouter den Hollander, W den Hollander, Y.F. Ramos +19 · 27 citations
Medicine · #Osteoarthritis Treatment and Mechanisms #Total Knee Arthroplasty Outcomes #Knee injuries and reconstruction techniques

paper · doi:10.1136/annrheumdis-2014-205980

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• DINCH Exposure Contributes to Osteoarthritis Pathogenesis via TSPO-Mediated Chondrotoxicity: Evidence from In Silico Prediction to Experimental Validation
• Fibroblast pathology in inflammatory joint disease
• Genome-wide mapping of DNA hydroxymethylation in osteoarthritic chondrocytes. [europepmc]
• Genome-wide DNA methylation study of hip and knee cartilage reveals embryonic organ and skeletal system morphogenesis as major pathways involved in osteoarthritis. [europepmc]
• Phlpp1 facilitates post-traumatic osteoarthritis and is induced by inflammation and promoter demethylation in human osteoarthritis. [europepmc]
• Increased DNA Methylation and Reduced Expression of Transcription Factors in Human Osteoarthritis Cartilage. [europepmc]
• DNA Methylation in Osteoarthritis. [europepmc]
• Identification of DNA methylation changes associated with disease progression in subchondral bone with site-matched cartilage in knee osteoarthritis. [europepmc]
• TWIST1 induces MMP3 expression through up-regulating DNA hydroxymethylation and promotes catabolic responses in human chondrocytes. [europepmc]
• The Epigenomic Landscape in Osteoarthritis. [europepmc]
• Integrative epigenomics, transcriptomics and proteomics of patient chondrocytes reveal genes and pathways involved in osteoarthritis. [europepmc]
• DNA Methylation in Osteoarthritis: Current Status and Therapeutic Implications. [europepmc]
• Identification of a novel, methylation-dependent, RUNX2 regulatory region associated with osteoarthritis risk. [europepmc]
• Chromatin accessibility landscape of articular knee cartilage reveals aberrant enhancer regulation in osteoarthritis. [europepmc]
• Identification of long non-coding RNAs expressed in knee and hip osteoarthritic cartilage. [europepmc]
• Genome-wide analysis of DNA methylation profile identifies differentially methylated loci associated with human intervertebral disc degeneration. [europepmc]
• Analysis of "old" proteins unmasks dynamic gradient of cartilage turnover in human limbs. [europepmc]
• Cartilage-gut-microbiome axis: a new paradigm for novel therapeutic opportunities in osteoarthritis. [europepmc]
• DNA hypomethylation during MSC chondrogenesis occurs predominantly at enhancer regions. [europepmc]
• Intraspecific and interspecific investigations of skeletal DNA methylation and femur morphology in primates. [europepmc]
• Elucidating Epigenetic Regulation by Identifying Functional cis-Acting Long Noncoding RNAs and Their Targets in Osteoarthritic Articular Cartilage. [europepmc]
• RNA Sequencing Reveals Interacting Key Determinants of Osteoarthritis Acting in Subchondral Bone and Articular Cartilage: Identification of IL11 and CHADL as Attractive Treatment Targets. [europepmc]
• DNA Methylation Signatures of Bone Metabolism in Osteoporosis and Osteoarthritis Aging-Related Diseases: An Updated Review. [europepmc]
• Critical Role of Synovial Tissue-Resident Macrophage and Fibroblast Subsets in the Persistence of Joint Inflammation. [europepmc]
• An epigenome-wide view of osteoarthritis in primary tissues. [europepmc]
• Peripheral Blood DNA Methylation-Based Machine Learning Models for Prediction of Knee Osteoarthritis Progression: Biologic Specimens and Data From the Osteoarthritis Initiative and Johnston County Osteoarthritis Project. [europepmc]
• The long non-coding RNA HOTAIR contributes to joint-specific gene expression in rheumatoid arthritis. [europepmc]