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Permutation-Free High-Order Interaction Tests

2025/06/06 by Zhaolu Liu, Liu, Zhaolu, Robert L. Peach +3
Computer Science · Mathematics · #Advanced Causal Inference Techniques #Bayesian Methods and Mixture Models #Bayesian Modeling and Causal Inference #FOS: Computer and information sciences #Machine Learning (stat.ML) #Methodology (stat.ME)

paper · pdf · doi:10.48550/arxiv.2506.05963

openalex publication_date 2025/06/06 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28

Abstract

Kernel-based hypothesis tests offer a flexible, non-parametric tool to detect high-order interactions in multivariate data, beyond pairwise relationships. Yet the scalability of such tests is limited by the computationally demanding permutation schemes used to generate null approximations. Here we introduce a family of permutation-free high-order tests for joint independence and partial factorisations of d variables. Our tests eliminate the need for permutation-based approximations by leveraging V-statistics and a novel cross-centring technique to yield test statistics with a standard normal limiting distribution under the null. We present implementations of the tests and showcase their efficacy and scalability through synthetic datasets. We also show applications inspired by causal discovery and feature selection, which highlight both the importance of high-order interactions in data and the need for efficient computational methods.

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