Prostaglandins limit nuclear actin rod formation during Drosophila oogenesis

2025/03/07 by Tina L. Tootle
Medicine · #Cardiac Imaging and Diagnostics #Colorectal Cancer Treatments and Studies #HER2/EGFR in Cancer Research

paper · doi:10.17912/micropub.biology.001571

openalex publication_date 2025/03/07 · openalex created_date 2025/04/22 · openalex updated_date 2026/07/28

Abstract

oogenesis. Loss of prostaglandin (PG) synthesis and signaling results in an increased frequency of cells with nuclear actin rods; there are less rods per cell, but the rods are longer. These findings suggest that loss of PGs results in increased nuclear actin and are consistent with prior findings assessing the roles of PGs in modulating endogenous nuclear actin. Thus, GFP-Actin rod formation can be used as a tool to screen for new regulators of nuclear actin.

Related

• An A-kinase anchoring protein is required for Protein kinase A regulatory subunit localization and morphology of actin structures during oogenesis inDrosophila
• Generation and maintenance of apical rib-like actin fibers in epithelial support cells of the Drosophila eye
• Actin cytoskeleton dynamics in mammalian oocyte meiosis†
• Genome organization regulates nuclear pore complex formation and promotes differentiation during Drosophila oogenesis
• Bitesize bundles F-actin and influences actin remodeling in syncytial Drosophila embryo development