2009/08/04 by Xuefeng Wang, Wang, Xuefeng, Ming Zhao +5
Biochemistry, Genetics and Molecular Biology · Engineering · Physics and Astronomy · #Advanced Biosensing Techniques and Applications #Chemical Physics (physics.chem-ph) #FOS: Physical sciences #Microfluidic and Bio-sensing Technologies #Optics (physics.optics) #Photonic and Optical Devices #physics.chem-ph #physics.optics
paper · pdf · doi:10.48550/arxiv.0908.0550
arxiv created 2009/08/04 · openalex publication_date 2009/08/04 · arxiv updated 2009/12/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
We observed water film accumulation on silica surfaces in the air to 2 picometer resolution using optical land-contrast (LC) interferometry. The land-contrast approach is non-destructive and allows real-time measurement of thickness variation of small molecular films on a surface. Water accumulation rates are observed to be different on bare or protein monolayer coated silica surfaces. This suggests that water contributes false signals to mass-sensitive biosensors for protein microarray.