Comparison of Fourier transform Raman spectra of mammalian and reptilian skin

1994/01/01 by Adrian C. Williams, Brian W. Barry, Brian Barry +1 · 1 citation
Agricultural and Biological Sciences · Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · Pharmacology, Toxicology and Pharmaceutics · #Advancements in Transdermal Drug Delivery #Bee Products Chemical Analysis #Biology #Biomedical engineering #Chemistry #Diffusion #Fourier transform #Human skin #Materials science #Medicine #Optics #Pharmacology #Physics #Raman spectroscopy #Spectroscopy Techniques in Biomedical and Chemical Research #Transdermal

paper · doi:10.1039/an9941900563

openalex publication_date 1994/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/06/11

Abstract

Human skin offers potential advantages for the administration of therapeutic agents for both local and systemic use. However, in studies of transdermal drug delivery, problems with the supply, storage, and use of human tissue have encouraged workers to seek alternative animal materials to model drug diffusion across human skin. We obtained Fourier transform Raman spectra from mammalian (human and pig) and reptilian (snake) skins, and considered structural dissimilarities in the light of differences observed in the diffusion of drugs across the tissues.

Cited by

• Quantitative analysis of microbicide concentrations in fluids, gels and tissues using confocal Raman spectroscopy. [europepmc]

Related

• Fourier transform Raman and infrared vibrational study of human skin: Assignment of spectral bands
• Raman spectra of human keratotic biopolymers: Skin, callus, hair and nail
• Raman microscopy for skin evaluation
• The Effects of ex vivo Handling Procedures on the Near‐Infrared Raman Spectra of Normal Mammalian Tissues
• Determining optical properties of skin ex-vivo: An inverse solution