NMR-based dynamics of free glycosaminoglycans in solution

2014/01/01 by Vitor H. Pomin · 1 citation
Biochemistry, Genetics and Molecular Biology · Chemistry · #Proteoglycans and glycosaminoglycans research #Glycosylation and Glycoproteins Research #Carbohydrate Chemistry and Synthesis

paper · doi:10.1039/c4an00531g

Abstract

Glycosaminoglycans (GAGs) comprise a special class of complex carbohydrates endowed with numerous biological functions. Most of these functions are regulated by conformational arrangements or dynamical properties of GAGs in solution. Nuclear magnetic resonance (NMR) is a powerful technique used for dynamic analyses. Spin relaxation, scalar couplings, chemical shifts and nuclear Overhauser effect resonances are the commonest NMR parameters utilized in such analyses. Computational molecular dynamics are also very often employed in conjunction with, or restrained by, the NMR dataset. This report aims at describing the major NMR-based information available so far concerning the dynamical properties of free GAGs in solution.

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