2011/04/18 by C. F. Royse, Colin Royse, David T. Andrews +9 · 139 citations
Medicine · Neuroscience · #Anesthesia #Anesthesia and Neurotoxicity Research #Artery #Cardiac, Anesthesia and Surgical Outcomes #Cognition #Coronary artery bypass surgery #Delirium #Desflurane #Incidence (geometry) #Intensive Care Unit Cognitive Disorders #Medicine #Neurocognitive #Postoperative cognitive dysfunction #Propofol #Psychiatry #Surgery
paper · doi:10.1111/j.1365-2044.2011.06704.x
published in Anaesthesia 66(6), 455-464 (Wiley)
openalex publication_date 2011/04/18 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
We investigated the influence of either propofol or desflurane on the incidence of postoperative cognitive dysfunction in a randomised trial of 180 patients undergoing coronary artery bypass surgery. The primary outcome was incidence of postoperative cognitive dysfunction at 3 months, defined as ≥1 SD deterioration in two or more of 12 neurocognitive tests. Secondary outcomes included early postoperative cognitive dysfunction (between days three and seven), delirium on day one, morbidity and length of hospital stay. Early postoperative cognitive dysfunction was significantly higher with propofol compared with desflurane (56/84 (67.5%) vs 41/83 (49.4%), respectively, p=0.018), but this effect was not seen at 3 months (10/87 (11.2%) vs 9/90 (10.0%), respectively. There was no difference in delirium (7/89 (7.9%) vs 12/91 (13.2%), respectively, length of hospital stay (median (IQR [range]) 7 (6-9 [4-15]) vs 6 (5-7 [5-16) days, respectively or other morbidities. Desflurane was associated with reduced early cognitive dysfunction.