2023/02/16 by Hongxing Wang, H.‐B. Wang, Yuan Jia +22 · 15 citations
Medicine · Neuroscience · #Intensive Care Unit Cognitive Disorders #Anesthesia and Sedative Agents #Anesthesia and Neurotoxicity Research
paper · pdf · doi:10.1111/anae.15983
Summary Dexmedetomidine might reduce delirium after cardiac surgery. We allocated 326 participants to an infusion of dexmedetomidine at a rate of 0.6 μg kg −1 for 10 min and then at 0.4 μg.kg −1 .h −1 until the end of surgery; 326 control participants received comparable volumes of saline. We detected delirium in 98/652 (15%) participants during the first seven postoperative days: 47/326 after dexmedetomidine vs. 51/326 after placebo, p = 0.62, adjusted relative risk (95%CI) 0.86 (0.56–1.33), p = 0.51. Postoperative renal impairment (Kidney Disease Improving Global Outcomes stages 1, 2 and 3) was detected in 46, 9 and 2 participants after dexmedetomidine and 25, 7 and 4 control participants, p = 0.040. Intra‐operative dexmedetomidine infusion did not reduce the incidence of delirium after cardiac valve surgery but might impair renal function.