2025/01/21 by Ruirui Liu, Liu, Ruirui, M. Swat +8 · 1 citation
Engineering · Mathematics · #Digital Transformation in Industry #Ergonomics and Human Factors #Mathematical Biology Tumor Growth
paper · pdf · doi:10.48550/arxiv.2501.11875
In this study, we present the Physical-Bio Translator, an agent-based simulation model designed to simulate cellular responses following irradiation. This simulation framework is based on a novel cell-state transition model that accurately reflects the characteristics of irradiated cells. To validate the Physical-Bio Translator, we performed simulations of cell phase evolution, cell phenotype evolution, and cell survival. The results indicate that the Physical-Bio Translator effectively replicates experimental cell irradiation outcomes, suggesting that digital cell irradiation experiments can be conducted via computer simulation, offering a more sophisticated model for radiation biology. This work lays the foundation for developing a robust and versatile digital twin at multicellular or tissue scales, aiming to comprehensively study and predict patient responses to radiation therapy.