The Primacy of Cognition in Schizophrenia.

2005/03/29 by R. Walter Heinrichs · 27 citations
Medicine · Arts and Humanities · Neuroscience · #Schizophrenia research and treatment #Mental Health and Psychiatry #Functional Brain Connectivity Studies

paper · doi:10.1037/0003-066x.60.3.229

Abstract

Cognitive tasks and concepts are used increasingly in schizophrenia science and treatment. Recent meta-analyses show that across a spectrum of research domains only cognitive measures distinguish a majority of schizophrenia patients from healthy people. Average effect sizes derived from common clinical tests of attention, memory, language, and reasoning are twice as large as those obtained in structural magnetic resonance imaging and positron emission tomography studies. Chronic stress, genes, brain disturbances, task structure, gender, and sociocultural background may all enhance the sensitivity of cognitive performance to schizophrenia. At the same time, disease heterogeneity and the presence of endophenotypes and subtypes within the patient population may place upper limits on the strength of any specific cognitive finding. Schizophrenia is a complex biobehavioral disorder that manifests itself primarily in cognition.

Citations

• Hippocampal Volume Reduction in Schizophrenia as Assessed by Magnetic Resonance Imaging
• The Endophenotype Concept in Psychiatry: Etymology and Strategic Intentions

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