2022/09/26 by Ireth García-Aguilar, García-Aguilar, Ireth, Steven Zwaan +3
Biochemistry, Genetics and Molecular Biology · Engineering · Materials Science · #Advanced Materials and Mechanics #Biological Physics (physics.bio-ph) #FOS: Physical sciences #Microtubule and mitosis dynamics #Soft Condensed Matter (cond-mat.soft) #Supramolecular Self-Assembly in Materials
paper · pdf · doi:10.48550/arxiv.2209.12884
openalex publication_date 2022/09/26 · openalex created_date 2022/09/28 · openalex updated_date 2026/07/28
We investigate the mechanical origin of polymorphic structures in two-dimensional tubulin assemblies, of which microtubules are the best known example. These structures feature twisted ribbons, flat tubulin sheets, macrotubules, and hoops, and they spontaneously assemble depending on the chemical environment. Upon modelling tubulin aggregates as minimally anisotropic elastic shells and using a combination of numerical simulations and analytical work, we show that the mechanical strain in tubulin lattices, originating from asymmetries at the single dimer level, naturally gives rise to polymorphic assemblies, among which cylinders and other tubular structures are predominant for a wide range of values of spontaneous curvature. Furthermore, our model suggests that switching the sign of the sheets' spontaneous Gaussian curvature from positive (i.e. sphere-like) to negative (i.e. saddle-like), could provide a possible route to microtubules disassembly.