2025/09/11 by Deni Hardiansyah, Bisma Barron Patrianesha, Hardiansyah, Deni +9 · 1 citation
Medicine · Pharmacology, Toxicology and Pharmaceutics · #Applied Physics (physics.app-ph) #Chemical Reactions and Isotopes #FOS: Physical sciences #Medical Imaging Techniques and Applications #Medical Physics (physics.med-ph) #Radiopharmaceutical Chemistry and Applications
paper · pdf · doi:10.48550/arxiv.2509.09755
openalex publication_date 2025/09/11 · openalex created_date 2025/09/29 · openalex updated_date 2026/07/30
This review discusses the current applications, advantages, and limitations of PBPK and PopPK models in radiopharmaceutical therapy (RPT). PBPK models simulate radiopharmaceutical kinetics by integrating prior physiological and drug parameter information, whereas PopPK models leverage population data to enhance individual dose estimation accuracy. Future directions include developing hybrid models, incorporating artificial intelligence, and establishing regulatory guidelines to promote their clinical adoption. Ultimately, these modeling strategies aim to enable precise, personalized RPT dosing, thereby improving therapeutic outcomes and safety.