TOBACCO SMOKING AS A POSSIBLE ETIOLOGIC FACTOR IN BRONCHIOGENIC CARCINOMA

1950/05/27 by ERNEST L. WYNDER, Ernest L. Wynder · 33 citations
Medicine · #Lung Cancer Treatments and Mutations #Lung Cancer Diagnosis and Treatment

paper · pdf · doi:10.1001/jama.1950.02910390001001

Abstract

<h3>General Increase.—</h3> There is rather general agreement that the incidence of bronchiogenic carcinoma has greatly increased in the last half-century. Statistical studies at the Charity Hospital of New Orleans (Ochsner and DeBakey),¹the St. Louis City Hospital (Wheeler)²and the Veterans Administration Hospital of Hines, Ill. (Avery)³have revealed that at these hospitals cancer of the lung is now the most frequent visceral cancer in men. Autopsy statistics throughout the world show a great increase in the incidence of bronchiogenic carcinoma in relation to cancer in general. Kenneway and Kennewat,⁴in a careful statistical study of death certificates in England and Wales from 1928 to 1945, have presented undoubted evidence of a great increase in deaths from cancer of the lung. In this country statistics compiled by the American Cancer Society show a similar trend during the past two decades.⁵ <h3>Tobacco as a Possible Cause</h3>

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