Two Cases of False-Positive Dengue Non-Structural Protein 1 (NS1) Antigen in Patients with Hematological Malignancies and a Review of the Literature on the Use of NS1 for the Detection of Dengue Infection

2014/11/11 by Shimin J. Chung, Shimin Jasmine Chung, Prabha U. Krishnan +3 · 10 citations
Medicine · #Mosquito-borne diseases and control #Viral Infections and Vectors #Malaria Research and Control

paper · pdf · doi:10.4269/ajtmh.14-0247

Abstract

Early diagnosis of dengue has been made easier in recent years owing to the advancement in diagnostic technologies. The rapid non-structural protein 1 (NS1) test strip is widely used in many developed and developing regions at risk of dengue. Despite the relatively high specificity of this test, we recently encountered two cases of false-positive dengue NS1 antigen in patients with underlying hematological malignancies. We reviewed the literature for causes of false-positive dengue NS1.

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