2008/07/07 by Maria Davidich, Davidich, Maria, Stefan Bornholdt +1
Biochemistry, Genetics and Molecular Biology · #Gene Regulatory Network Analysis #Microbial Metabolic Engineering and Bioproduction #Bacterial Genetics and Biotechnology
paper · pdf · doi:10.48550/arxiv.0807.1013
Methods of modeling cellular regulatory networks as diverse as differential\nequations and Boolean networks co-exist, however, without any closer\ncorrespondence to each other. With the example system of the fission yeast cell\ncycle control network, we here set the two approaches in relation to each\nother. We find that the Boolean network can be formulated as a specific\ncoarse-grained limit of the more detailed differential network model for this\nsystem. This lays the mathematical foundation on which Boolean networks can be\napplied to biological regulatory networks in a controlled way.\n