2014/04/01 by Mirko Maraldi, Krishna Garikipati, Maraldi, Mirko +1
Biochemistry, Genetics and Molecular Biology · Chemistry · Physics and Astronomy · #Actin #Biochemistry #Biological Physics (physics.bio-ph) #Biology #Biophysics #Cell #Cell mechanics #Cellular Mechanics and Interactions #Chemistry #Contractility #Cytoskeleton #FOS: Biological sciences #FOS: Physical sciences #Force Microscopy Techniques and Applications #Linkage (software) #Lipid Membrane Structure and Behavior #Mechanics #Physics #Stress fiber #Subcellular Processes (q-bio.SC) #physics.bio-ph #q-bio.SC
paper · pdf · doi:10.48550/arxiv.1404.0389
published in arXiv (Cornell University) (Cornell University) · 22 pages, 6 figures, 1 table, accepted in Biomechanics and Modeling in Mechanobiology
openalex publication_date 2014/04/01 · arxiv created 2014/04/23 · arxiv updated 2014/04/25 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/06
In this communication, we propose a model to study the non-equilibrium process by which actin stress fibers develop force in contractile cells. The emphasis here is on the non-equilibrium thermodynamics, which is necessary to address the mechanics as well as the chemistry of dynamic cell contractility. In this setting we are able to develop a framework that relates (a) the dynamics of force generation within the cell and (b) the cell response to external stimuli to the chemical processes occurring within the cell, as well as to the mechanics of linkage between the stress fibers, focal adhesions and extra-cellular matrix.