2025/10/10 by Madeleine Kördel, Maria Meier, Anne Kühnel +1 · 1 voice · 3 citations
Neuroscience · Psychology · Environmental Science · #Stress Responses and Cortisol #Optimism, Hope, and Well-being #Climate Change and Health Impacts
paper · doi:10.1016/j.ynstr.2025.100764
= 2.42, NNT = 10.63). In contrast, the effects of sex hormones on cortisol responses were smaller and more variable, with both progesterone and estradiol showing weak and inconsistent associations. Our results highlight a robust modulatory role of metabolic state, specifically glucose availability, on HPA axis reactivity, while evidence for sex hormone effects remains inconclusive. Future research should focus on better harmonization of designs concerning sex hormones and systematically examine interactions between metabolic and hormonal states to better explain sex differences in the prevalences of metabolic and stress-related disorders.