2025/10/10 by Madeleine Kördel, Maria Meier, Anne Kühnel +1 · 1 voice · 6 citations
Environmental Science · Neuroscience · Psychology · #Climate Change and Health Impacts #Endogeny #Estrogen #Glucocorticoid #Hormone #Hydrocortisone #Metabolic control analysis #Metabolic regulation #Optimism, Hope, and Well-being #Stress Responses and Cortisol
paper · doi:10.1016/j.ynstr.2025.100764
published in Neurobiology of Stress 39, 100764 (Elsevier BV)
openalex created_date 2025/10/10 · openalex publication_date 2025/10/10 · openalex updated_date 2026/08/05
= 2.42, NNT = 10.63). In contrast, the effects of sex hormones on cortisol responses were smaller and more variable, with both progesterone and estradiol showing weak and inconsistent associations. Our results highlight a robust modulatory role of metabolic state, specifically glucose availability, on HPA axis reactivity, while evidence for sex hormone effects remains inconclusive. Future research should focus on better harmonization of designs concerning sex hormones and systematically examine interactions between metabolic and hormonal states to better explain sex differences in the prevalences of metabolic and stress-related disorders.