2026/01/01 by Olivia R. Christiano, Sebastian Michelmann
Physics and Astronomy · Neuroscience · Medicine · #Atomic and Subatomic Physics Research #Functional Brain Connectivity Studies #Optical Imaging and Spectroscopy Techniques
paper · doi:10.1162/imag.a.1218
Abstract Optically pumped magnetometers (OPMs) offer a promising advancement in noninvasive neuroimaging via magnetoencephalography (MEG), but establishing their reliability and comparability to existing methods remains an ongoing endeavor. Here, we evaluated OPM recordings by assessing their test-retest reliability and comparing them to functional magnetic resonance imaging (fMRI) and intracranial electroencephalography (iEEG) recordings. Data were collected from three independent participant groups during repeated viewings of a movie segment. In 7 canonical frequency bands (δ: 0.5–4 Hz, θ: 4–8 Hz, α: 8–12 Hz, β: 12–28 Hz, γ1: 28–46 Hz, γ2: 55–70 Hz, and HF: 64–116 Hz), as well as a broadband (BB: 0.5–116 Hz) signal, we quantified the signal consistency (1) within individuals, (2) across subjects, and (3) across modalities. OPM exhibited widespread reliability, particularly in lower frequency bands; spatial patterns resembled those of fMRI and iEEG in visual and auditory regions. Cross-modal analyses revealed robust correspondence between OPM and both fMRI and iEEG, including inverse correlations at low frequencies and positive correlations at higher frequencies in the OPM-fMRI comparison, consistent with known relationships between oscillatory power and BOLD responses. Comparisons of signal-to-noise (SNR) estimates further revealed that in some regions, the SNR of cross-modal alignment exceeded within-modality reliability, suggesting that bridging between modalities can sometimes enhance SNR by attenuating reliably shared noise. Our findings demonstrate that OPM consistently captures stimulus-driven neural dynamics that converge with established modalities.