2025/06/20 by Roy, Arkaprava, Sarkar, Abhra
Mathematics · Medicine · Neuroscience · #Advanced Neuroimaging Techniques and Applications #FOS: Computer and information sciences #Functional Brain Connectivity Studies #Methodology (stat.ME) #Tensor decomposition and applications
paper · pdf · doi:10.48550/arxiv.2506.16668
openalex publication_date 2025/06/20 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
We introduce a novel longitudinal mixed model for analyzing complex multidimensional functional data, addressing challenges such as high-resolution, structural complexities, and computational demands. Our approach integrates dimension reduction techniques, including basis function representation and Tucker tensor decomposition, to model complex functional (e.g., spatial and temporal) variations, group differences, and individual heterogeneity while drastically reducing model dimensions. The model accommodates multiplicative random effects whose marginalization yields a novel Tucker-decomposed covariance-tensor framework. To ensure scalability, we employ semi-orthogonal mode matrices implemented via a novel graph-Laplacian-based smoothness prior with low-rank approximation, leading to an efficient posterior sampling method. A cumulative shrinkage strategy promotes sparsity and enables semiautomated rank selection. We establish theoretical guarantees for posterior convergence and demonstrate the method's effectiveness through simulations, showing significant improvements over existing techniques. Applying the method to Alzheimer's Disease Neuroimaging Initiative (ADNI) neuroimaging data reveals novel insights into local brain changes associated with disease progression, highlighting the method's practical utility for studying cognitive decline and neurodegenerative conditions.