Just bypass it: mechanisms of DNA damage tolerance

2025/08/21 by Sidak Minocha, Marta Oliva-Santiago, Sampath Amitash Gadi +1 · 2 voices · 3 citations
Biochemistry, Genetics and Molecular Biology · #DNA Repair Mechanisms #Carcinogens and Genotoxicity Assessment #CRISPR and Genetic Engineering

paper · doi:10.1016/j.tibs.2025.07.004

Cited by

• Mechanistic coupling of enzymatic activities at the replisome
• Structural basis for fork reversal and RAD51 regulation by the SCF ubiquitin ligase complex of F-box helicase 1. [europepmc]
• An updated view on lagging strand DNA replication: implications for the replication stress response. [europepmc]

Discussions

• It is not always safe to repair DNA Damage. Sometimes, cells "just bypass it". During DNA replication, repair of lesions on DNA can be dangerous. Cells instead "tolerate" DNA damage and focus on fini [bsky, 55 points, 2 comments]
• Sometimes DNA replication hits a 🛑 roadblock. Cells don’t stop; they take clever detours (DNA damage tolerance) 🚗💨 to keep genomes intact. That’s the focus of our new review in @cp-trendsbiochem.b [bsky, 12 points, 0 comments]