Long runs of homozygosity are reliable genomic markers of inbreeding depression

2025/08/01 by Christopher C. Kyriazis, Jacqueline A. Robinson, Kirk E. Lohmueller · 1 voice · 18 citations
Biochemistry, Genetics and Molecular Biology · #Genetic Mapping and Diversity in Plants and Animals #Genetic and phenotypic traits in livestock #Animal Genetics and Reproduction

paper · doi:10.1016/j.tree.2025.06.013

Citations

• Population genomics of recovery and extinction in Hawaiian honeycreepers
• Measuring individual inbreeding in the age of genomics: marker-based measures are better than pedigrees

Cited by

• Endemic but not eroded: Genomic distinctiveness and conservation genomics of the <scp>British</scp> swallowtail butterfly ( <i>Papilio machaon britannicus</i> )
• Accurate Runs of Homozygosity Estimation From Low Coverage Genome Sequences in Non‐Model Species
• Genome‐Wide Homozygosity Predicts Inbreeding Depression in the Hihi/Stitchbird ( <i>Notiomystis cincta</i> ) Better Than Realised Load
• Genomic erosion across avian lineages in the context of their evolutionary history
• Genomic diversity and the domestication history of cotton ( <i>Gossypium hirsutum</i> )
• Pathogen purification and genetic characterization of SPF BWEL chicken population. [europepmc]
• Integrating mosquito genomics into simulation modeling: opportunities for better-informed biocontrol. [europepmc]
• Accurate Runs of Homozygosity Estimation From Low Coverage Genome Sequences in Non-Model Species. [europepmc]
• Genomic divergence of leopards in the Cape Floristic Region of South Africa: potential drivers for local adaptation. [europepmc]
• Genetic recovery in an alpine climate-sensitive pika species during upward treeline shift. [europepmc]
• Genomic erosion across avian lineages in the context of their evolutionary history. [europepmc]
• Predicting extinction risk of gibbons from genomes of extinct Yunnan lar gibbon. [europepmc]
• Genomic insights into fragmentation and translocation in European green toads. [europepmc]
• No Pedigree, No Problem: Genomic Inbreeding Tracks Genetic Rescue With High Resolution. [europepmc]
• Population Genetic Differentiation and Runs of Homozygosity Analysis of Bursaphelenchus xylophilus in Southwest China. [europepmc]
• Genomic diversity and the domestication history of cotton ( Gossypium hirsutum ). [europepmc]
• Genome-Wide Homozygosity Predicts Inbreeding Depression in the Hihi/Stitchbird ( Notiomystis cincta ) Better Than Realised Load. [europepmc]
• Reduced Genetic Load and Inbreeding in Reintroduced African Wild Dogs Reflect the Benefits of Admixture. [europepmc]

Discussions

• I am thrilled to share this paper outlining some ideas I’ve been thinking about for a little while on a simple but powerful approach for predicting risk of inbreeding depression from long runs of homo [bsky, 54 points, 1 comments]