2020/01/22 by Leihao Wei, Yannan Lin, Wei, Leihao +3
Computer Science · Medicine · #AI in cancer detection #Advanced Image Processing Techniques #Computer Vision and Pattern Recognition (cs.CV) #FOS: Computer and information sciences #FOS: Electrical engineering #Image and Video Processing (eess.IV) #Machine Learning (cs.LG) #Machine Learning (stat.ML) #Radiomics and Machine Learning in Medical Imaging #electronic engineering #information engineering
paper · pdf · doi:10.48550/arxiv.2001.08741
openalex publication_date 2020/01/22 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
Computer-Aided-Diagnosis (CADx) systems assist radiologists with identifying and classifying potentially malignant pulmonary nodules on chest CT scans using morphology and texture-based (radiomic) features. However, radiomic features are sensitive to differences in acquisitions due to variations in dose levels and slice thickness. This study investigates the feasibility of generating a normalized scan from heterogeneous CT scans as input. We obtained projection data from 40 low-dose chest CT scans, simulating acquisitions at 10%, 25% and 50% dose and reconstructing the scans at 1.0mm and 2.0mm slice thickness. A 3D generative adversarial network (GAN) was used to simultaneously normalize reduced dose, thick slice (2.0mm) images to normal dose (100%), thinner slice (1.0mm) images. We evaluated the normalized image quality using peak signal-to-noise ratio (PSNR), structural similarity index (SSIM) and Learned Perceptual Image Patch Similarity (LPIPS). Our GAN improved perceptual similarity by 35%, compared to a baseline CNN method. Our analysis also shows that the GAN-based approach led to a significantly smaller error (p-value < 0.05) in nine studied radiomic features. These results indicated that GANs could be used to normalize heterogeneous CT images and reduce the variability in radiomic feature values.