2025/06/19 by Alfasly, Saghir, Alabtah, Ghazal, Tizhoosh, H. R.
Computer Science · #AI in cancer detection #Advanced Neural Network Applications #Computer Vision and Pattern Recognition (cs.CV) #Digital Imaging for Blood Diseases #FOS: Computer and information sciences #FOS: Electrical engineering #Image and Video Processing (eess.IV) #electronic engineering #information engineering
paper · pdf · doi:10.48550/arxiv.2506.16631
openalex publication_date 2025/06/19 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
This study investigates the critical problem of overfitting in deep learning models applied to histopathology image analysis. We show that simply adopting and fine-tuning large-scale models designed for natural image analysis often leads to suboptimal performance and significant overfitting when applied to histopathology tasks. Through extensive experiments with various model architectures, including ResNet variants and Vision Transformers (ViT), we show that increasing model capacity does not necessarily improve performance on histopathology datasets. Our findings emphasize the need for customized architectures specifically designed for histopathology image analysis, particularly when working with limited datasets. Using Oesophageal Adenocarcinomas public dataset, we demonstrate that simpler, domain-specific architectures can achieve comparable or better performance while minimizing overfitting.