Sexually dimorphic control of crossover distribution by the conserved ATPase PCH-2 in C. elegans

2025/08/25

paper · doi:10.17912/micropub.biology.001802

Abstract

<p>Meiotic crossover recombination is essential for accurate chromosome segregation and the creation of new allele combinations that drive natural selection during evolution. Thus, the number and distribution of crossovers is exquisitely controlled. We have shown that the pachytene checkpoint component and conserved AAA-ATPase <a href="http://www.wormbase.org/db/get?name=WBGene00008641;class=Gene" id="b51d182c-5b5d-4c44-9525-0ffba78fee70">PCH-2</a> controls crossover number and distribution during oogenesis in <i><a href="https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&amp;id=6239" id="d9fc6f3b-33ec-473b-ac91-20e13feacb0c">C. elegans</a></i>. To test if <a href="http://www.wormbase.org/db/get?name=WBGene00008641;class=Gene" id="ddc35136-8a7a-49db-9558-b4816fd9efde">PCH-2</a> has similar effects during spermatogenesis, we monitored recombination across a single chromosome in control and <i><a href="http://www.wormbase.org/db/get?name=WBGene00008641;class=Gene" id="07e59144-c51e-4672-a77c-e070e094b171">pch-2</a></i> mutant males. Our results demonstrate that <a href="http://www.wormbase.org/db/get?name=WBGene00008641;class=Gene" id="313b56e5-c46c-4857-9576-15232fed25ea">PCH-2</a>'s effect on crossover distribution during spermatogenesis is different than we observed in oogenesis, exhibiting sexual dimorphism.</p>

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