2024/12/31 by Kasdallah, N., Achoura S, BenSalem H +7
#brainstemneoplasms–primary– congenital–tumors–intracranial–newborn–infant #nouveau-né - néoplasie – tumeurs cérébrales – congénitale -
paper · doi:10.71566/pist-rmp-194948
Background and aims : Brain Tumors with early childhood onset are mostly congenital (CBTs). They are most often, defined, as tumors presenting within 60 days after birth, are extremely rare. Even after several investigations have been performed, a clear direction for diagnosis and treatment of fetal intracranial tu- mors is still lacking. We reviewed the cases of CBTs managed in our unit. Methods : A 15-year retrospective study (2001-2015) of the cases of CBTs hospitalized in our unit was performed. Clinical, radiological with magnetic resonance imaging, histopathological findings and outco- me were analyzed. Results : We identified three cases of CBT diagnosed in two male and one female infant. The diagnosis was performed in postnatal period for the three cases. CBT was revealed by refractory status epilepticus at day one of life for first newborn, delayed walking for the second newborn (at 18 months) and bulging fontanels at two months of life for the third newborn. Clinical outcome in the first case with pilocytic astrocytoma grade I diagnosis resulted in vegetative state after delayed resection of the tumor (8 months). The second patient with ependymoma grade II underwent successful resection of the tumor and is still alive with concentration disorders. In the third case with infantile desmoplastic astrocytoma grade I diagnosis, surgery was success- fully performed at two months 26 days of life. Conclusion : This study sheds light on the difficulty of prenatal diagnosis, neonatal diagnostic, histological, prognostic, and therapeutic characteristics of CBTs. Further studies are needed to clarify its clini- cal characteristics and establish recommendations for management