2024/01/01 by Struwe, Henry, Li, Heng, Schrödter, Finn +4
Biochemistry, Genetics and Molecular Biology · Medicine · #540 #Anions #Cyclization #Hydrocarbons #Marine Sponges and Natural Products #Microbial Natural Products and Biosynthesis #Peptides and proteins #Plant biochemistry and biosynthesis #Reaction products
paper · doi:10.15488/20156
openalex publication_date 2024/01/01 · openalex created_date 2025/12/10 · openalex updated_date 2026/07/01
New diterpenoids are accessible from non-natural FPP derivatives as substrates for an enzymatic elongation cyclization cascade using the geranylgeranyl pyrophosphate synthase (GGPPS) from Streptomyces cyaneofuscatus and the spata-13,17-diene synthase (SpS) from Streptomyces xinghaiensis. This approach led to four new biotransformation products including three new cyclododecane cores and a macrocyclic ether. For the first time, a 1,12-terpene cyclization was observed when shifting the central olefinic double bond toward the geminial methyl groups creating a nonconjugated 1,4-diene.