Mothering a Female Saint: Susan Warner's Dialogic Role in 'The Wide, Wide World.'

1995/03/22 by Takashi Horiguchi, Kunihiro Uryu, Benoit I. Giasson +10 · 27 citations
Arts and Humanities · Chemistry · Medicine · Neuroscience · #Aesthetics #Alzheimer's disease #Alzheimer's disease research and treatments #American and British Literature Analysis #Art #Art history #Aside #Atrophy #Biology #Chemistry #Corticobasal degeneration #Dialogic #History #Law #Literary criticism #Literature #Literature: history, themes, analysis #Medicine #Modernist Literature and Criticism #Molecular biology #Neurodegeneration #Neurofibrillary tangle #Neuroscience and Neuropharmacology Research #Order (exchange) #Parkinson's Disease Mechanisms and Treatments #Parkinsonism #Pathology #Philosophy #Political science #Politics #Progressive supranuclear palsy #Reading (process) #SAINT #Scholarship #Senile plaques #Sociology #Tau protein #Thioflavin

paper · pdf · doi:10.1016/s0002-9440(10)63462-1

published in American Journal Of Pathology 22(1), 58-31 (Elsevier BV)

openalex publication_date 1995/03/22 · openalex created_date 2016/06/24 · openalex updated_date 2026/08/01

Abstract

Oxidative and nitrative injury is implicated in the pathogenesis of Alzheimer's disease (AD) and Down syndrome (DS), but no direct evidence links this type of injury to the formation of neurofibrillary tau lesions. To address this, we generated a monoclonal antibody (mAb), n847, which recognizes nitrated tau and alpha-synuclein. n847 detected nitrated tau in the insoluble fraction of AD, corticobasal degeneration (CBD), and Pick's disease (PiD) brains by Western blots. Immunohistochemistry (IHC) showed that n847 labeled neurons in the hippocampus and neocortex of AD and DS brains. Double-label immunofluorescence with n847 and an anti-tau antibody revealed partial co-localization of tau and n847 positive tangles, while n847 immunofluorescence and Thioflavin-S double-staining showed that a subset of n847-labeled neurons were Thioflavin-S-positive. In addition, immuno-electron microscopy revealed that tau-positive filaments in tangle-bearing neurons were also labeled by n847 and IHC of other tauopathies showed that some of glial and neuronal tau pathologies in CBD, progressive supranuclear palsy, PiD, and frontotemporal dementia with parkinsonism linked to chromosome 17 also were n847-positive. Finally, nitrated and Thioflavin-S-positive tau aggregates were generated in a oligodendrocytic cell line after treatment with peroxynitrite. Taken together, these findings imply that nitrative injury is directly linked to the formation of filamentous tau inclusions.

Citations

• Neuropathological stageing of Alzheimer-related changes

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