5-Lipoxygenase and Leukotriene B4 Receptor Are Expressed in Human Pancreatic Cancers But Not in Pancreatic Ducts in Normal Tissue

2002/08/01 by René Hennig, Xian-Zhong Ding, Xianzhong Ding +10 · 190 citations
Medicine · #Adenocarcinoma #Apoptosis #Biochemistry #Biology #Cancer #Cancer cell #Cancer research #Cancer, Stress, Anesthesia, and Immune Response #Chemokine receptors and signaling #Ductal cells #Endocrinology #Immunohistochemistry #Immunology #Inflammatory mediators and NSAID effects #Medicine #Pancreas #Pancreatic cancer #Pancreatic disease #Pathology #Receptor

paper · pdf · doi:10.1016/s0002-9440(10)64198-3

published in American Journal Of Pathology 161(2), 421-428 (Elsevier BV)

openalex publication_date 2002/08/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

Cited by

• Lipoxygenases at the Intersection of Infection and Carcinogenesis
• Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets
• LY293111 improves efficacy of gemcitabine therapy on pancreatic cancer in a fluorescent orthotopic model in athymic mice. [europepmc]
• Restoration of leukotriene B(4)-12-hydroxydehydrogenase/15- oxo-prostaglandin 13-reductase (LTBDH/PGR) expression inhibits lung cancer growth in vitro and in vivo. [europepmc]
• Targeted chiral lipidomics analysis of bioactive eicosanoid lipids in cellular systems. [europepmc]
• Eicosanoids and cancer. [europepmc]
• Cyclooxygenase-deficient pancreatic cancer cells use exogenous sources of prostaglandins. [europepmc]
• Overexpression of 5-lipoxygenase in sporadic colonic adenomas and a possible new aspect of colon carcinogenesis. [europepmc]
• 5-lipoxygenase: underappreciated role of a pro-inflammatory enzyme in tumorigenesis. [europepmc]
• Cyclooxygenase- and lipoxygenase-mediated DNA damage. [europepmc]
• Lipoxygenase and Cyclooxygenase Pathways and Colorectal Cancer Prevention. [europepmc]
• Genetic variation in the lipoxygenase pathway and risk of colorectal neoplasia. [europepmc]
• OXER1, a G protein-coupled oxoeicosatetraenoid receptor, mediates the survival-promoting effects of arachidonate 5-lipoxygenase in prostate cancer cells. [europepmc]
• Targeted chiral analysis of bioactive arachidonic Acid metabolites using liquid-chromatography-mass spectrometry. [europepmc]
• Ablation of 5-lipoxygenase mitigates pancreatic lesion development. [europepmc]
• Acinar Cell Production of Leukotriene B 4 Contributes to Development of Neurogenic Pancreatitis in Mice. [europepmc]
• Cross-Talk between Cancer Cells and the Tumour Microenvironment: The Role of the 5-Lipoxygenase Pathway. [europepmc]
• Eicosanoids and cancer. [europepmc]
• Zileuton suppresses cholangiocarcinoma cell proliferation and migration through inhibition of the Akt signaling pathway. [europepmc]
• Human cytomegalovirus infection is correlated with enhanced cyclooxygenase-2 and 5-lipoxygenase protein expression in breast cancer. [europepmc]
• Arachidonic acid-derived hydroxyeicosatetraenoic acids are positively associated with colon polyps in adult males: a cross-sectional study. [europepmc]
• Influence of Lipoxygenase Inhibition on Glioblastoma Cell Biology. [europepmc]
• Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets. [europepmc]
• Neutrophil Extracellular Traps (NETs) in Cancer Metastasis. [europepmc]
• Membrane Lipid Derivatives: Roles of Arachidonic Acid and Its Metabolites in Pancreatic Physiology and Pathophysiology. [europepmc]
• ALOX5 acts as a key role in regulating the immune microenvironment in intrahepatic cholangiocarcinoma, recruiting tumor-associated macrophages through PI3K pathway. [europepmc]
• The role of human 5-Lipoxygenase (5-LO) in carcinogenesis - a question of canonical and non-canonical functions. [europepmc]