KIT Extracellular and Kinase Domain Mutations in Gastrointestinal Stromal Tumors

2000/03/01 by Marcia L. Lux, Brian P. Rubin, Tara L. Biase +9 · 30 citations
Medicine · Immunology and Microbiology · #Gastrointestinal Tumor Research and Treatment #Mast cells and histamine #Gastrointestinal disorders and treatments

paper · pdf · doi:10.1016/s0002-9440(10)64946-2

Citations

• Mutations in Exon 11 of c-Kit Occur Preferentially in Malignant versus Benign Gastrointestinal Stromal Tumors and Do Not Occur in Leiomyomas or Leiomyosarcomas

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• The Complexity of KIT Gene Mutations and Chromosome Rearrangements and Their Clinical Correlation in Gastrointestinal Stromal (Pacemaker Cell) Tumors
• Co expression of SCF and KIT in gastrointestinal stromal tumours (GISTs) suggests an autocrine/paracrine mechanism
• Gain-of-function mutations of platelet-derived growth factor receptor α gene in gastrointestinal stromal tumors
• Diagnosis of gastrointestinal stromal tumors: A consensus approach
• Gastrointestinal Stromal Tumors, Intramural Leiomyomas, and Leiomyosarcomas in the Rectum and Anus
• Mutations in exons 9 and 13 of KIT gene are rare events in gastrointestinal stromal tumors. A study of 200 cases. [europepmc]
• c-KIT and PDGFRA in breast phyllodes tumours: overexpression without mutations? [europepmc]
• Surgical treatment and prognostic analysis for gastrointestinal stromal tumors (GISTs) of the small intestine: before the era of imatinib mesylate. [europepmc]
• Synthesis and positron emission tomography studies of carbon-11-labeled imatinib (Gleevec). [europepmc]
• Protein kinase C-theta regulates KIT expression and proliferation in gastrointestinal stromal tumors. [europepmc]
• Management of resectable gastrointestinal stromal tumor. [europepmc]
• Adjuvant imatinib mesylate after resection of localised, primary gastrointestinal stromal tumour: a randomised, double-blind, placebo-controlled trial. [europepmc]
• Targeting human gastrointestinal stromal tumor cells with a quadruplex-binding small molecule. [europepmc]
• Identification of c-kit gene mutations in primary adenoid cystic carcinoma of the salivary gland. [europepmc]
• Chromosome copy number changes carry prognostic information independent of KIT/PDGFRA point mutations in gastrointestinal stromal tumors. [europepmc]
• The role of mutational analysis of KIT and PDGFRA in gastrointestinal stromal tumors in a clinical setting. [europepmc]
• Updates on the management of gastrointestinal stromal tumors. [europepmc]
• Gastrointestinal stromal tumors. [europepmc]
• Membrane-to-nucleus signaling links insulin-like growth factor-1- and stem cell factor-activated pathways. [europepmc]
• Modular nanotransporters for targeted intracellular delivery of drugs: folate receptors as potential targets. [europepmc]
• Gastrointestinal stromal tumor - an evolving concept. [europepmc]
• Platelet-Derived Growth Factor Receptor-α Regulates Proliferation of Gastrointestinal Stromal Tumor Cells With Mutations in KIT by Stabilizing ETV1. [europepmc]
• C-Kit Promotes Growth and Migration of Human Cardiac Progenitor Cells via the PI3K-AKT and MEK-ERK Pathways. [europepmc]
• Germline mutations of KIT in gastrointestinal stromal tumor (GIST) and mastocytosis. [europepmc]
• Molecular characterization and pathogenesis of gastrointestinal stromal tumor. [europepmc]
• Neoadjuvant and adjuvant therapy for gastrointestinal stromal tumors. [europepmc]
• Clinical Diagnosis of Gastrointestinal Stromal Tumor (GIST): From the Molecular Genetic Point of View. [europepmc]
• Targeted Deep Sequencing Uncovers Cryptic KIT Mutations in KIT/PDGFRA/SDH/RAS-P Wild-Type GIST. [europepmc]
• Relationships between highly recurrent tumor suppressor alterations in 489 leiomyosarcomas. [europepmc]
• Role and significance of c-KIT receptor tyrosine kinase in cancer: A review. [europepmc]