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MorphSAM: Learning the Morphological Prompts from Atlases for Spine Image Segmentation

2025/06/16 by Dingwei Fan, Junyong Zhao, Fan, Dingwei +13
Computer Science · Engineering · Neuroscience · #Brain Tumor Detection and Classification #FOS: Electrical engineering #Image and Video Processing (eess.IV) #Medical Image Segmentation Techniques #Medical Imaging and Analysis #electronic engineering #information engineering

paper · pdf · doi:10.48550/arxiv.2506.13094

openalex publication_date 2025/06/16 · openalex created_date 2025/10/13 · openalex updated_date 2026/07/28

Abstract

Spine image segmentation is crucial for clinical diagnosis and treatment of spine diseases. The complex structure of the spine and the high morphological similarity between individual vertebrae and adjacent intervertebral discs make accurate spine segmentation a challenging task. Although the Segment Anything Model (SAM) has been proposed, it still struggles to effectively capture and utilize morphological information, limiting its ability to enhance spine image segmentation performance. To address these challenges, in this paper, we propose a MorphSAM that explicitly learns morphological information from atlases, thereby strengthening the spine image segmentation performance of SAM. Specifically, the MorphSAM includes two fully automatic prompt learning networks, 1) an anatomical prompt learning network that directly learns morphological information from anatomical atlases, and 2) a semantic prompt learning network that derives morphological information from text descriptions converted from the atlases. Then, the two learned morphological prompts are fed into the SAM model to boost the segmentation performance. We validate our MorphSAM on two spine image segmentation tasks, including a spine anatomical structure segmentation task with CT images and a lumbosacral plexus segmentation task with MR images. Experimental results demonstrate that our MorphSAM achieves superior segmentation performance when compared to the state-of-the-art methods.

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