2017/05/14 by Adam Mahdi, Mahdi, Adam, Dragana Nikolić +11
Medicine · #Acute Ischemic Stroke Management #FOS: Biological sciences #Optical Imaging and Spectroscopy Techniques #Quantitative Methods (q-bio.QM) #Radiation Dose and Imaging #Traumatic Brain Injury and Neurovascular Disturbances
paper · pdf · doi:10.48550/arxiv.1705.04942
openalex publication_date 2017/05/14 · openalex created_date 2022/10/02 · openalex updated_date 2026/07/28
Dynamic cerebral autoregulation, that is the transient response of cerebral\nblood flow to changes in arterial blood pressure, is currently assessed using a\nvariety of different time series methods and data collection protocols. In the\ncontinuing absence of a gold standard for the study of cerebral autoregulation\nit is unclear to what extent does the assessment depend on the choice of a\ncomputational method and protocol. We use continuous measurements of blood\npressure and cerebral blood flow velocity in the middle cerebral artery from\nthe cohorts of 18 normotensive subjects performing sit-to-stand manoeuvre. We\nestimate cerebral autoregulation using a wide variety of black-box approaches\n(ARI, Mx, Sx, Dx, FIR and ARX) and compare them in the context of\nreproducibility and variability. For all autoregulation indices, considered\nhere, the ICC was greater during the standing protocol, however, it was\nsignificantly greater (Fisher's Z-test) for Mx (p < 0.03), Sx (p<0.003) and Dx\n(p<0.03). In the specific case of the sit-to-stand manoeuvre, measurements\ntaken immediately after standing up greatly improve the reproducibility of the\nautoregulation coefficients. This is generally coupled with an increase of the\nwithin-group spread of the estimates.\n